Yes, I use PhotoShop and Painter software as my "palette," and a digitizing tablet and stylus as my "brush" but I still have to create the image. I start with either a photo I've taken or a sketch or watercolor painting I've done. That's the bottom "layer" I work from. I create another semi-transparent layer on top of this, and start painting with my stylus. As I work, I can change the transparency of the top layer, so that I can check my source image and the top painted layer to see how the image is coming along.
When I'm happy with what I've "painted" I save the top layer as a .jpg image. Then I'm ready to print it. I can print on almost any substrate - paper, canvas, metal, plexiglass and more. Depending on the resolution of the image I created, I can print it in a wide range of sizes too. Most of the time, these digital paintings are printed just one time as a unique digital painting. I make a thumbnail archival image for my records and then the digital file is destroyed. These unique digital paintings come with a certificate of authenticity that there is just the single image, making them as "original" as a watercolor painting, drawing, etc.
Right now, I have a selection of digital paintings on display at the Southern Arizona Watercolor Guild Gallery at Williams Centre in Tucson. They'll be up through August 15, 2018. If you want to see some examples of my work in this contemporary medium, visit the gallery. Summer hours are 11AM - 4PM, Thursday through Sunday. The gallery is right behind Olive Garden on the southwest corner of Broadway and Craycroft.